Anticancer potential of lichens' secondary metabolites

Z Solárová, A Liskova, M Samec, P Kubatka… - Biomolecules, 2020 - mdpi.com
Lichens produce different classes of phenolic compounds, including anthraquinones,
xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed …

[HTML][HTML] Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathways

E Sabouni, MM Nejad, S Mojtabavi… - Biomedicine & …, 2023 - Elsevier
Colorectal cancer (CRC) is a dangerous form of cancer that affects the gastrointestinal tract.
It is a major global health concern, and the aggressive behavior of tumor cells makes it …

Cancer metabolism control by natural products: Pyruvate kinase M2 targeting therapeutics

AH El‐Far, SK Al Jaouni, X Li, J Fu - Phytotherapy Research, 2022 - Wiley Online Library
Glycolysis is the primary source of energy for cancer growth and metastasis. The shift in
metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis is called the …

Bioactive lichen secondary metabolites and their presence in species from Chile

E Poulsen-Silva, F Gordillo-Fuenzalida, C Atala… - Metabolites, 2023 - mdpi.com
Lichens are symbiotic organisms composed of at least one fungal and one algal species.
They are found in different environments around the world, even in the poles and deserts …

In Vitro Anticancer Activity and Oxidative Stress Biomarkers Status Determined by Usnea barbata (L.) FH Wigg. Dry Extracts

V Popovici, L Bucur, G Vochita, D Gherghel, CT Mihai… - Antioxidants, 2021 - mdpi.com
Lichens represent an important resource for common traditional medicines due to their
numerous metabolites that can exert diverse pharmacological activities including anticancer …

Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical …

S Fakhri, SZ Moradi, F Faraji, L Kooshki… - Cancer and Metastasis …, 2024 - Springer
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

Physciosporin suppresses mitochondrial respiration, aerobic glycolysis, and tumorigenesis in breast cancer

İ Taş, M Varlı, Y Son, J Han, D Kwak, Y Yang, R Zhou… - Phytomedicine, 2021 - Elsevier
Background Physciosporin (PHY) is one of the potent anticancer lichen compound.
Recently, PHY was shown to suppress colorectal cancer cell proliferation, motility, and …

Libertellenone T, a novel compound isolated from endolichenic fungus, induces G2/M phase arrest, apoptosis, and autophagy by activating the ROS/JNK pathway in …

CDB Gamage, JH Kim, Y Yang, İ Taş, SY Park, R Zhou… - Cancers, 2023 - mdpi.com
Simple Summary Libertellenone T (B) is a natural product derived from the secondary
metabolites of the endolichenic fungus, Pseudoplectania sp. In this study, we investigated …

1′-O-methyl-averantin isolated from the endolichenic fungus Jackrogersella sp. EL001672 suppresses colorectal cancer stemness via sonic Hedgehog and Notch …

M Varlı, EY Lee, Y Yang, R Zhou, İ Taş, S Pulat… - Scientific Reports, 2023 - nature.com
Endolichenic fungi are host organisms that live on lichens and produce a wide variety of
secondary metabolites. Colorectal cancer stem cells are capable of self-renewal and …

Lichens as a repository of bioactive compounds: an open window for green therapy against diverse cancers

TUH Dar, SA Dar, SU Islam, ZA Mangral, R Dar… - Seminars in Cancer …, 2022 - Elsevier
Lichens, algae and fungi-based symbiotic associations, are sources of many important
secondary metabolites, such as antibiotics, anti-inflammatory, antioxidants, and anticancer …