Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …

Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …

Cellular processes are carried out by many genes, and their study and optimization requires
multiple levers by which they can be independently controlled. The most common method is …

Biocontainment systems that couple environmental sensing with circuit-based control of cell
viability could be used to prevent escape of genetically modified microbes into the …

Abstract The 'Standard European Vector Architecture'database (SEVA-DB, http://seva. cnb.
csic. es) was conceived as a user-friendly, web-based resource and a material clone …

Heterologous pathways used in metabolic engineering may produce intermediates toxic to
the cell. Dynamic control of pathway enzymes could prevent the accumulation of these …

Bacterial therapies possess many unique mechanisms for treating cancer that are
unachievable with standard methods. Bacteria can specifically target tumours, actively …

Microbial consortia are ubiquitous in nature and are implicated in processes of great
importance to humans, from environmental remediation and wastewater treatment to …

Synthetic genetic programs are built from circuits that integrate sensors and implement
temporal control of gene expression,,,. Transcriptional circuits are layered by using …

Cell-free protein synthesis is becoming a powerful technique to construct and to study
complex informational processes in vitro. Engineering synthetic gene circuits in a test tube …