Bayesian parameter estimation and population pharmacokinetics
AH Thomson, B Whiting - Clinical pharmacokinetics, 1992 - Springer
The widespread application of Bayesian parameter estimation in the area of therapeutic
drug monitoring (TDM) has prompted the need for well conducted population studies to …
drug monitoring (TDM) has prompted the need for well conducted population studies to …
The pharmacology of anesthetic drugs in elderly patients
SL Shafer - Anesthesiology clinics of North america, 2000 - Elsevier
Elderly patients need smaller doses of anesthetic drugs than younger patients. This is
clinically obvious. Based on both teaching and experience, anesthesiologists have learned …
clinically obvious. Based on both teaching and experience, anesthesiologists have learned …
Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil: I. Model development
CF Minto, TW Schnider, TD Egan… - Survey of …, 1997 - journals.lww.com
MINTO, CHARLES F.; SCHNIDER, THOMAS W.; EGAN, TALMAGE D.; YOUNGS,
ELIZABETH; LEMMENS, HARRYJ M.; GAMBUS, PEDRO L.; BILLARD, VALERIE; HOKE …
ELIZABETH; LEMMENS, HARRYJ M.; GAMBUS, PEDRO L.; BILLARD, VALERIE; HOKE …
[图书][B] Nonlinear models for repeated measurement data
M Davidian - 2017 - taylorfrancis.com
Nonlinear measurement data arise in a wide variety of biological and biomedical
applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the …
applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the …
[图书][B] The art of modeling
PL Bonate - 2006 - Springer
The focus of this book is primarily on the development of pharmacokinetic and
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …
The importance of modeling interoccasion variability in population pharmacokinetic analyses
MO Karlsson, LB Sheiner - Journal of pharmacokinetics and …, 1993 - Springer
Individual pharmacokinetic parameters may change randomly between study occasions.
Analysis of simulated data with NONMEM shows that ignoring such interoccasion variability …
Analysis of simulated data with NONMEM shows that ignoring such interoccasion variability …
Building population pharmacokineticpharmacodynamic models. I. Models for covariate effects
JW Mandema, D Verotta, LB Sheiner - Journal of pharmacokinetics and …, 1992 - Springer
One major task in clinical pharmacology is to determine the pharmacokinetic-
pharmacodynamic (PK-PD) parameters of a drug in a patient population. NONMEM is a …
pharmacodynamic (PK-PD) parameters of a drug in a patient population. NONMEM is a …
Automated covariate model building within NONMEM
EN Jonsson, MO Karlsson - Pharmaceutical research, 1998 - Springer
Purpose. One important task in population pharmacokinetic/pharmacodynamic model
building is to identify the relationships between the parameters and demographic factors …
building is to identify the relationships between the parameters and demographic factors …
Nonlinear mixed effects modeling for slash pine dominant height growth following intensive silvicultural treatments
Z Fang, RL Bailey - Forest science, 2001 - academic.oup.com
A modified Richard's growth model with nonlinear mixed effects is developed for modeling
slash pine (Pinus elliottii Engelm.) dominant height growth in conjunction with different …
slash pine (Pinus elliottii Engelm.) dominant height growth in conjunction with different …
Remifentanil pharmacokinetics in obese versus lean patients.
TD Egan, B Huizinga, SK Gupta, RL Jaarsma… - …, 1998 - europepmc.org
Background Remifentanil is a short-acting opioid whose pharmacokinetics have been
characterized in detail. However, the impact of obesity on remifentanil pharmacokinetics has …
characterized in detail. However, the impact of obesity on remifentanil pharmacokinetics has …