Background: Obesity and type 2 diabetes are strongly associated pathologies, currently
considered as a worldwide epidemic problem. Understanding the mechanisms that drive the …

Intuitively, it is easy to understand why we search for G protein-coupled receptor (GPCR)
antagonists. It is obviously to block a functionality of a specific receptor potentially linked to …

Background. Increasing evidence has suggested that obesity affects the occurrence and
progression of osteoarthritis (OA). However, the underlying molecular mechanism that …

26RFa is a neuropeptide that activates the rhodopsin-like G protein-coupled receptor
QRFPR/GPR103. This peptidergic system is involved in the regulation of a wide array of …

Lately, amino-functionalized N ω-carbamoylated arginines were introduced as arginine
surrogates enabling peptide labeling. However, this approach is hardly compatible with …

Background: Obesity and type 2 diabetes are strongly associated pathologies, currently
considered as a worldwide epidemic problem. Understanding the mechanisms that drive the …

Abstract Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is
an ether phospholipid mediator associated with platelet coagulation, but also subserves …

The overall synthetic approach was used to prepare a series of novel compounds
pyrazolopyridine. Because of its high efficiency and selectiveness, the combined molecules …