Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …

The endocannabinoid system has emerged as a key player in the control of eating.
Endocannabinoids, including 2-arachidonoylglycerol (2-AG) and anandamide (AEA) …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

Mutations in the GNAO1 gene cause a complex constellation of neurological disorders
including epilepsy, developmental delay, and movement disorders. GNAO1 encodes Gα o …

Antibiotic resistance has become an increasing challenge in the treatment of various
infectious diseases, especially those associated with biofilm formation on biotic and abiotic …

Dopamine neurons in the ventral tegmental area (VTA) are powerful regulators of
depression-related behavior. Dopamine neuron activity is altered in chronic stress-based …

Prolonged or excessive stress may induce emotional and cognitive disturbances, and is a
risk factor for mental illnesses. Using rodent chronic stress models of depression, roles of …

Abstract Phosphodiesterase 4 (PDE4) is a promising target for the treatment of Parkinson's
disease (PD). However, the underlying mechanism has not yet been well elucidated …

Phospholipase C (PLC) plays pivotal roles in regulating various cellular functions by
metabolizing phosphatidylinositol 4, 5-bisphosphate in the plasma membrane. This process …

Physical exercise improves memory and cognition in physiological aging and Alzheimer's
disease (AD), but the mechanisms remain poorly understood. Here, we test the hypothesis …