Background: An ENDO-European Reference Network (ERN) initiative was launched that
was endorsed by the European Society for Pediatric Endocrinology and the European …

This perspective is partly review and partly proposal. N-degrons and C-degrons are
degradation signals whose main determinants are, respectively, the N-terminal and C …

The N-degron pathway targets proteins that bear a destabilizing residue at the N terminus
for proteasome-dependent degradation. In yeast, Ubr1—a single-subunit E3 ligase—is …

Macroautophagy (hereafter referred to as autophagy) is a process in which organelles
termed autophagosomes deliver cytoplasmic constituents to lysosomes for degradation …

A wealth of data and comprehensive reviews exist on pancreas development in mammals,
primarily mice, and other vertebrates. By contrast, human pancreatic development has been …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

The ubiquitin–proteasome system degrades an enormous variety of proteins that contain
specific degradation signals, or'degrons'. Besides the degradation of regulatory proteins …

Protein misfolding is linked to a wide array of human disorders, including Alzheimer's
disease, Parkinson's disease and type II diabetes,. Protective cellular protein quality control …

The N-end rule pathway is a proteolytic system in which N-terminal residues of short-lived
proteins are recognized by recognition components (N-recognins) as essential components …

Eukaryotic protein degradation by the proteasome and the lysosome is a dynamic and
complex process in which ubiquitin has a key regulatory role. The distinctive morphology of …