The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

The gonadotropic axis is centrally controlled by a complex regulatory network of excitatory
and inhibitory signals that is activated at puberty. Recently, loss of function mutations of the …

Metastin is a novel peptide that was recently isolated from human placenta as the
endogenous ligand of an orphan heptahelical receptor, hOT7T175. Metastin has been …

Loss-of-function mutations of the gene encoding GPR54, the putative receptor for the KiSS-1-
derived peptide metastin, have been recently associated with hypogonadotropic …

The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its
relationship to other lymphomas are largely unknown. This is partly because of the technical …

Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …

Kisspeptins, the products of KiSS-1 gene, and their receptor, GPR54, have recently emerged
as essential gatekeepers of reproduction, mainly through regulation of GnRH secretion at …

KiSS-1 was originally identified as a metastasis suppressor gene encoding an array of
structurally related peptides, namely kisspeptins, which acting through the G protein-coupled …