The VHL/HIF axis in the development and treatment of pheochromocytoma/paraganglioma

S Peng, J Zhang, X Tan, Y Huang, J Xu… - Frontiers in …, 2020 - frontiersin.org
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors
originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic …

Pheochromocytomas and hypertension

JM Pappachan, NN Tun, G Arunagirinathan… - Current hypertension …, 2018 - Springer
Abstract Purpose of Review Pheochromocytomas and paragangliomas (PPGLs) are
uncommon catecholamine-producing neuroendocrine neoplasms that usually present with …

Sunitinib for metastatic progressive phaeochromocytomas and paragangliomas: results from FIRSTMAPPP, an academic, multicentre, international, randomised …

E Baudin, B Goichot, A Berruti, J Hadoux, S Moalla… - The Lancet, 2024 - thelancet.com
Background No randomised controlled trial has ever been done in patients with metastatic
phaeochromocytomas and paragangliomas. Preclinical and first clinical evidence suggested …

Antiangiogenic therapies for pheochromocytoma and paraganglioma

C Jimenez, S Fazeli… - Endocrine-related …, 2020 - erc.bioscientifica.com
Metastatic pheochromocytomas and paragangliomas are rare, highly vascular tumors that
spread primarily to the lymph nodes, skeletal tissue, lungs, and liver. Tumor morbidity is …

[HTML][HTML] Pre-clinical phaeochromocytoma and paraganglioma models: cell lines, animal models, and a human primary culture model

K Wang, A Fischer, U Maccio, C Hantel… - Best Practice & …, 2024 - Elsevier
While the establishment of human phaeochromocytoma and paraganglioma (PPGL) cell
lines has proven to be particularly difficult over several decades of research, there are other …

From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma

C Lepoutre-Lussey, C Thibault, A Buffet, A Morin… - Molecular and Cellular …, 2016 - Elsevier
Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors
characterized by a high frequency of hereditary forms. Based on transcriptome classification …

[HTML][HTML] Sunitinib malate (SU-11248) reduces tumour burden and lung metastasis in an intratibial human xenograft osteosarcoma mouse model

RMR Kumar, MJE Arlt, A Kuzmanov… - American journal of …, 2015 - ncbi.nlm.nih.gov
Osteosarcoma is a rare type of cancer that commonly occurs as a primary bone tumour in
children and adolescents and is associated with a poor clinical outcome. Despite complex …

Animal and cell culture models of PPGLs–achievements and limitations

B Karna, NS Pellegata, H Mohr - Hormone and Metabolic …, 2024 - thieme-connect.com
Research on rare tumors heavily relies on suitable models for basic and translational
research. Paragangliomas (PPGL) are rare neuroendocrine tumors (NET), developing from …

Rodent models of pheochromocytoma, parallels in rodent and human tumorigenesis

C Lussey-Lepoutre, A Buffet, A Morin… - Cell and Tissue …, 2018 - Springer
Paragangliomas and pheochromocytomas are rare neuroendocrine tumors characterized by
a large spectrum of hereditary predisposition. Based on gene expression profiling …

Modulation of vascular response after injury in the rat Achilles tendon alters healing capacity

CN Riggin, AB Rodriguez, SN Weiss… - Journal of …, 2021 - Wiley Online Library
Tendons are relatively hypovascular but become hypervascular during both injury and
degeneration. This is due to the angiogenic response, or the formation of new blood vessels …