The VHL/HIF axis in the development and treatment of pheochromocytoma/paraganglioma
S Peng, J Zhang, X Tan, Y Huang, J Xu… - Frontiers in …, 2020 - frontiersin.org
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors
originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic …
originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic …
Pheochromocytomas and hypertension
JM Pappachan, NN Tun, G Arunagirinathan… - Current hypertension …, 2018 - Springer
Abstract Purpose of Review Pheochromocytomas and paragangliomas (PPGLs) are
uncommon catecholamine-producing neuroendocrine neoplasms that usually present with …
uncommon catecholamine-producing neuroendocrine neoplasms that usually present with …
Sunitinib for metastatic progressive phaeochromocytomas and paragangliomas: results from FIRSTMAPPP, an academic, multicentre, international, randomised …
E Baudin, B Goichot, A Berruti, J Hadoux, S Moalla… - The Lancet, 2024 - thelancet.com
Background No randomised controlled trial has ever been done in patients with metastatic
phaeochromocytomas and paragangliomas. Preclinical and first clinical evidence suggested …
phaeochromocytomas and paragangliomas. Preclinical and first clinical evidence suggested …
Antiangiogenic therapies for pheochromocytoma and paraganglioma
C Jimenez, S Fazeli… - Endocrine-related …, 2020 - erc.bioscientifica.com
Metastatic pheochromocytomas and paragangliomas are rare, highly vascular tumors that
spread primarily to the lymph nodes, skeletal tissue, lungs, and liver. Tumor morbidity is …
spread primarily to the lymph nodes, skeletal tissue, lungs, and liver. Tumor morbidity is …
[HTML][HTML] Pre-clinical phaeochromocytoma and paraganglioma models: cell lines, animal models, and a human primary culture model
K Wang, A Fischer, U Maccio, C Hantel… - Best Practice & …, 2024 - Elsevier
While the establishment of human phaeochromocytoma and paraganglioma (PPGL) cell
lines has proven to be particularly difficult over several decades of research, there are other …
lines has proven to be particularly difficult over several decades of research, there are other …
From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma
C Lepoutre-Lussey, C Thibault, A Buffet, A Morin… - Molecular and Cellular …, 2016 - Elsevier
Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors
characterized by a high frequency of hereditary forms. Based on transcriptome classification …
characterized by a high frequency of hereditary forms. Based on transcriptome classification …
[HTML][HTML] Sunitinib malate (SU-11248) reduces tumour burden and lung metastasis in an intratibial human xenograft osteosarcoma mouse model
RMR Kumar, MJE Arlt, A Kuzmanov… - American journal of …, 2015 - ncbi.nlm.nih.gov
Osteosarcoma is a rare type of cancer that commonly occurs as a primary bone tumour in
children and adolescents and is associated with a poor clinical outcome. Despite complex …
children and adolescents and is associated with a poor clinical outcome. Despite complex …
Animal and cell culture models of PPGLs–achievements and limitations
Research on rare tumors heavily relies on suitable models for basic and translational
research. Paragangliomas (PPGL) are rare neuroendocrine tumors (NET), developing from …
research. Paragangliomas (PPGL) are rare neuroendocrine tumors (NET), developing from …
Rodent models of pheochromocytoma, parallels in rodent and human tumorigenesis
C Lussey-Lepoutre, A Buffet, A Morin… - Cell and Tissue …, 2018 - Springer
Paragangliomas and pheochromocytomas are rare neuroendocrine tumors characterized by
a large spectrum of hereditary predisposition. Based on gene expression profiling …
a large spectrum of hereditary predisposition. Based on gene expression profiling …
Modulation of vascular response after injury in the rat Achilles tendon alters healing capacity
CN Riggin, AB Rodriguez, SN Weiss… - Journal of …, 2021 - Wiley Online Library
Tendons are relatively hypovascular but become hypervascular during both injury and
degeneration. This is due to the angiogenic response, or the formation of new blood vessels …
degeneration. This is due to the angiogenic response, or the formation of new blood vessels …