Context To improve the prognosis of upper tract urothelial carcinoma (UTUC), clinicians
have used neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (AC) before or after …

Inhibitors of fibroblast growth factor receptor (FGFR) represent an outstanding treatment
approach for selected patients with urothelial cancer (UC). These agents are changing the …

Background Urothelial carcinomas of the upper urinary tract (UTUCs) are rare, with poorer
stage-for-stage prognosis than urothelial carcinomas of the urinary bladder. No international …

Upper urinary tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Its
molecular pathogenesis, however, is poorly understood, with no useful biomarkers available …

Purpose: To investigate genomic differences between urothelial carcinomas of the upper
tract (UTUC) and bladder (UCB), with a focus on defining the clonal relatedness of …

Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical
phenotype. To define the biological features driving this phenotype, we performed an …

Current non-invasive approaches for detection of urothelial cancers are suboptimal. We
developed a test to detect urothelial neoplasms using DNA recovered from cells shed into …

Background Characterization of the different genomic alterations (GAs) in urothelial
carcinoma (UC), by site of origin, may identify contrasting therapeutic opportunities and …

Background Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are
potential biomarkers and key regulators of tumour development and progression. SOX2 …

Purpose: The purpose of this study is to characterize the mutational landscape across the
spectrum of urothelial carcinoma (UC) to identify mutational features and potential …