Axon degeneration is a prominent early feature of most neurodegenerative disorders and
can also be induced directly by nerve injury in a process known as Wallerian degeneration …

Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same
time, these organelles generate reactive oxygen and nitrogen species as byproducts …

Objectives N‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox
modulatory compound currently in trials for many neurological and psychiatric disorders …

Abstract X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder.
The disease is caused by mutations in the ABCD1 gene that encodes the peroxisomal …

Adrenoleukodystrophy (ALD) is a rare X‐linked disease caused by a mutation of the
peroxisomal ABCD1 gene. This review summarizes our current understanding of the …

X-Linked adrenoleukodystrophy (ALD) is a peroxisomal metabolic disorder with a highly
complex clinical presentation. ALD is caused by mutations in the ABCD1 gene, which leads …

X-linked adrenoleukodystrophy (X-ALD) is the most frequent peroxisomal disease. The two
main clinical phenotypes of X-ALD are adrenomyeloneuropathy (AMN) and inflammatory …

Reduction-oxidation or “redox” reactions are an integral part of a broad range of cellular
processes such as gene expression, energy metabolism, protein import and folding, and …

The exact pathogenesis of Parkinson's disease (PD) is still unknown and proper
mechanisms that correspond to the disease remain unidentified. It is understood that PD is …

Peroxisomes contain numerous enzymatic activities that are important for mammalian
physiology. Patients lacking either all peroxisomal functions or a single enzyme or …