Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Abstract Objective In 2015, the Academy for Eating Disorders collaborated with international
patient, advocacy, and parent organizations to craft the 'Nine Truths About Eating Disorders' …

Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …

Abstract See Schrag and Politis (doi: 10.1093/aww190) for a scientific commentary on this
article. Apathy, which can occur separately or in combination with depression and anxiety, is …

Psychedelics probably alter states of consciousness by disrupting how the higher
association cortex governs bottom-up sensory signals. Individual hallucinogenic drugs are …

Brain imaging techniques enable the visualization of serotonin transporter (SERT)
occupancy as a measure of the proportion of SERT blocked by an antidepressant at a given …

Background Premenstrual dysphoric disorder (PMDD) disrupts the lives of millions of people
each month. The timing of symptoms suggests that hormonal fluctuations play a role in the …

Many studies suggest that the hippocampus is involved in the pathophysiology of psychiatric
disorders, especially major depressive disorder (MDD) and schizophrenia. Especially, in …

Neuromodulators transform animal behaviors. Recent research has demonstrated the
importance of both sustained and transient change in neuromodulators, likely due to tonic …