Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Abstract Angiotensin II (Ang II) increases adhesion molecules, cytokines and chemokines
and exerts a proinflammatory effect on leucocytes, endothelial cells and vascular smooth …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

Obesity is a leading cause of death worldwide because of its associated inflammatory
disorders such as hypertension, cardiovascular and kidney diseases, dyslipidemia, glucose …

Angiotensin II (Ang II) is considered the major final mediator of the renin-angiotensin system.
The actions of Ang II have been implicated in many cardiovascular conditions, such as …

Angiotensin II type 2 (AT2) receptors can be regarded as an endogenous repair system,
because the AT2 receptor is upregulated in tissue damage and mediates tissue protection. A …

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …

Abstract'Oxidative stress' is a term defining states of elevated reactive oxygen species (ROS)
levels. Normally, ROS control several physiological processes, such as host defence …

Recent data support the idea that the effects of RAS are not restricted to the cardiovascular
and renal systems. Importantly, RAS modulates free radical production and the cellular …