Most natural (or biological) materials are complex composites whose mechanical properties
are often outstanding, considering the weak constituents from which they are assembled …

Living cells can sense mechanical forces and convert them into biological responses.
Similarly, biological and biochemical signals are known to influence the abilities of cells to …

The attachment of single-celled organisms, namely bacteria and fungi, to abiotic surfaces is
of great interest to both the scientific and medical communities. This is because the …

How physical force is sensed by cells and transduced into cellular signaling pathways is
poorly understood. Previously, we showed that tyrosine phosphorylation of p130Cas (Cas) …

A complete understanding of a protein-folding mechanism requires description of the
distribution of microscopic pathways that connect the folded and unfolded states. This …

I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …

Here we review the applications of atomic force microscopy to the study of samples of
biological origin. Emphasis is given to provide the reader with information on the broad …

Progress in the application of the atomic force microscope (AFM) to imaging and
manipulating biomolecules is the result of improved instrumentation, sample preparation …

Spider capture silk is a natural material that outperforms almost any synthetic material in its
combination of strength and elasticity. The structure of this remarkable material is still largely …

The introduction of disulfide bonds into proteins creates additional mechanical barriers and
limits the unfolded contour length (ie, the maximal extension) measured by single-molecule …