TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

The mechanosensory neurons of touch and their mechanisms of activation

A Handler, DD Ginty - Nature Reviews Neuroscience, 2021 - nature.com
Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

A microbiome-dependent gut–brain pathway regulates motivation for exercise

L Dohnalová, P Lundgren, JRE Carty, N Goldstein… - Nature, 2022 - nature.com
Exercise exerts a wide range of beneficial effects for healthy physiology 1. However, the
mechanisms regulating an individual's motivation to engage in physical activity remain …

PIEZO1 transduces mechanical itch in mice

RZ Hill, MC Loud, AE Dubin, B Peet, A Patapoutian - Nature, 2022 - nature.com
Itch triggers scratching, a behavioural defence mechanism that aids in the removal of
harmful irritants and parasites. Chemical itch is triggered by many endogenous and …

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

J Kupari, D Usoskin, M Parisien, D Lou, Y Hu… - Nature …, 2021 - nature.com
Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

[HTML][HTML] An atlas of vagal sensory neurons and their molecular specialization

J Kupari, M Häring, E Agirre, G Castelo-Branco… - Cell reports, 2019 - cell.com
Sensory functions of the vagus nerve are critical for conscious perceptions and for
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …

Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles

R Baron, C Maier, N Attal, A Binder, D Bouhassira… - Pain, 2017 - journals.lww.com
Patients with neuropathic pain are heterogeneous in etiology, pathophysiology, and clinical
appearance. They exhibit a variety of painrelated sensory symptoms and signs (sensory …

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

SE Murthy, MC Loud, I Daou, KL Marshall… - Science translational …, 2018 - science.org
The brush of a feather and a pinprick are perceived as distinct sensations because they are
detected by discrete cutaneous sensory neurons. Inflammation or nerve injury can disrupt …

Deconstructing the sensation of pain: The influence of cognitive processes on pain perception

K Wiech - Science, 2016 - science.org
Phenomena such as placebo analgesia or pain relief through distraction highlight the
powerful influence cognitive processes and learning mechanisms have on the way we …

Neural circuits for pain: recent advances and current views

C Peirs, RP Seal - Science, 2016 - science.org
The mammalian nervous system encodes many different forms of pain, from those that arise
as a result of short-term low-grade interactions with noxious thermal, chemical, or …