Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Exercise exerts a wide range of beneficial effects for healthy physiology 1. However, the
mechanisms regulating an individual's motivation to engage in physical activity remain …

Itch triggers scratching, a behavioural defence mechanism that aids in the removal of
harmful irritants and parasites. Chemical itch is triggered by many endogenous and …

Sensory functions of the vagus nerve are critical for conscious perceptions and for
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …

Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

Patients with neuropathic pain are heterogeneous in etiology, pathophysiology, and clinical
appearance. They exhibit a variety of painrelated sensory symptoms and signs (sensory …

The brush of a feather and a pinprick are perceived as distinct sensations because they are
detected by discrete cutaneous sensory neurons. Inflammation or nerve injury can disrupt …

Phenomena such as placebo analgesia or pain relief through distraction highlight the
powerful influence cognitive processes and learning mechanisms have on the way we …

The mammalian nervous system encodes many different forms of pain, from those that arise
as a result of short-term low-grade interactions with noxious thermal, chemical, or …