Abstract Background The Infectious Diseases Society of America (IDSA) is committed to
providing up-to-date guidance on the treatment of antimicrobial-resistant (AMR) infections …

Multidrug resistance (MDR) represents a serious global threat due to the rapid global spread
and limited antimicrobial options for treatment of difficult-to-treat (DTR) infections sustained …

Abstract Objective Ceftazidime–avibactam (CAZ-AVI) is a novel synthetic β-lactamase
inhibitor combination. Although the combination has been available clinically for only a few …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

The β-lactams are the most widely used antibacterial agents worldwide. These antibiotics, a
group that includes the penicillins and cephalosporins, are covalent inhibitors that target …

As a class, the b-lactams are the most commonly prescribed and clinically dependable
antimicrobials in the United States, representing more than 65% of injected antibiotic …

Microbial resistance is a serious threat to human health worldwide. Among the World Health
Organisation's list of priority resistant bacteria, three are listed as critical—the highest level of …

Epistasis, the non-additive effect of mutations, can provide combinatorial improvements to
enzyme activity that substantially exceed the gains from individual mutations. Yet the …

The natural aquatic environment is a significant contributor to the development and
circulation of clinically significant antibiotic resistance genes (ARGs). The potential for the …

Introduction OXA-48 and NDM are amongst the most prevalent carbapenemase types
associated with Klebsiella pneumoniae worldwide, with an increase in their prevalence in …