Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations

AI Ritchie, JA Wedzicha - Clinics in chest medicine, 2020 - chestmed.theclinics.com
Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are episodes of
symptom worsening 1 that have significant adverse consequences for patients. 2 The …

Systemic manifestations and comorbidities of COPD

PJ Barnes, BR Celli - European respiratory journal, 2009 - Eur Respiratory Soc
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a
complex disease involving more than airflow obstruction. Airflow obstruction has profound …

A wireless patch for the monitoring of C-reactive protein in sweat

J Tu, J Min, Y Song, C Xu, J Li, J Moore… - Nature biomedical …, 2023 - nature.com
The quantification of protein biomarkers in blood at picomolar-level sensitivity requires
labour-intensive incubation and washing steps. Sensing proteins in sweat, which would …

[HTML][HTML] The nature of small-airway obstruction in chronic obstructive pulmonary disease

JC Hogg, F Chu, S Utokaparch, R Woods… - … England Journal of …, 2004 - Mass Medical Soc
Background Chronic obstructive pulmonary disease (COPD) is a major public health
problem associated with long-term exposure to toxic gases and particles. We examined the …

Infection in the pathogenesis and course of chronic obstructive pulmonary disease

S Sethi, TF Murphy - New England Journal of Medicine, 2008 - Mass Medical Soc
New molecular, cellular, and immunologic techniques used to study host–pathogen
interactions have led to a reexamination of the role of infection in chronic obstructive …

Immunology of asthma and chronic obstructive pulmonary disease

PJ Barnes - Nature Reviews Immunology, 2008 - nature.com
Asthma and chronic obstructive pulmonary disease (COPD) are both obstructive airway
diseases that involve chronic inflammation of the respiratory tract, but the type of …

Immunologic aspects of chronic obstructive pulmonary disease

MG Cosio, M Saetta, A Agusti - New England Journal of Medicine, 2009 - Mass Medical Soc
This review is an account of how pulmonary damage caused by cigarette smoke and other
environmental toxins can incite inflammatory and immunologic reactions that culminate in …

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

PJ Barnes, SD Shapiro… - European Respiratory …, 2003 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …

COPD exacerbations: defining their cause and prevention

JA Wedzicha, TAR Seemungal - The lancet, 2007 - thelancet.com
Exacerbations of chronic obstructive pulmonary disease (COPD) are episodes of worsening
of symptoms, leading to substantial morbidity and mortality. COPD exacerbations are …

Pathophysiology of airflow limitation in chronic obstructive pulmonary disease

JC Hogg - The Lancet, 2004 - thelancet.com
The airflow limitation that defines chronic obstructive pulmonary disease (COPD) is the
result of a prolonged time constant for lung emptying, caused by increased resistance of the …