The drug discovery has now evolved into a much more scientific and rational process due to
better understanding of biological processes and the underlying chemistry, owing to the …

Gliclazide is a sulfonylurea frequently prescribed for the management of type 2 diabetes
mellitus in elderly patients and for patients with chronic renal or hepatic diseases. Even …

Chemical study of the whole plant of Leucas zeylanica (L.) B. Br. has led to isolation of a
new norditerpenoid isomer (1), along with 29 known compounds, including one …

The poor solubility of the antidiabetic drug gliclazide (Glc) is due to its hydrophobic nature.
This research is aimed at improving Glc's solubility and drug release profile, as well as at …

Montelukast is a potent and selective antagonist of the cysteinyl leukotriene receptor 1
subtype (CysLT1) and widely used in the form of oral tablets and granules for asthma …

Background: This study aimed to develop a sensitive, rapid method based on HPLC-MS/MS
for the quantification of Montelukast in human plasma utilizing Montelukast-D6 as an internal …

A new simple, specific, accurate, precise and robust normal phase high performance thin
layer chromatography (HPTLC) method were developed and validated for simultaneous …

Background Montelukast (MT) is a leukotriene D4 antagonist. It is an effective and safe
medicine for the prophylaxis and treatment of chronic asthma. It is also used to prevent acute …

Aim: The aim of this study was to determine levels of montelukast in human milk and to
develop a simple, sensitive analytical method using mass spectrometry. Methods: Milk …

A sensitive, specific and accurate liquid chromatography–tandem mass spectrometry (LC–
MS/MS) method was developed and validated for the simultaneous determination of seven …