Epigenetic regulation of gene expression is an increasingly well-understood concept that
explains much of the contribution of an organism's environment and experience to its …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of
human cancer genetics. But this area has become increasingly visible with a growing …

Genomic imprinting affects several dozen mammalian genes and results in the expression of
those genes from only one of the two parental chromosomes. This is brought about by …

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by …

Recent investigations have implicated long antisense noncoding RNAs in the epigenetic
regulation of chromosomal domains. Here we show that Kcnq1ot1 is an RNA polymerase II …

Complementary sets of genes are epigenetically silenced in male and female gametes in a
process termed genomic imprinting. The Dnmt3L gene is expressed during gametogenesis …

Recent studies have demonstrated that transplanted bone marrow cells can turn into
unexpected lineages including myocytes, hepatocytes, neurons and many others. A …