The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Background Visual loss in glaucoma is associated with pathological changes in retinal
ganglion cell (RGC) axons and a slow decline in the RGC population. Age and elevated …

Background Multiple sclerosis (MS) is often accompanied by optic nerve inflammation. And
some patients experience permanent vision loss. We examined if the grade of optic nerve …

Retinitis pigmentosa (RP) is an important cause of irreversible blindness worldwide and
lacks effective treatment strategies. Although mutations are the primary cause of RP …

Glaucoma was previously thought to be caused only through an elevated intraocular
pressure as a sole trigger. Emerging evidence indicates that the pathogenesis of glaucoma …

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of secreted
growth factors and binds with high affinity to the TrkB tyrosine kinase receptors. BDNF is a …

Activation of neurotrophic factor signaling is a promising therapy for neurodegeneration.
However, the transient nature of ligand-dependent activation limits its effectiveness. In this …

In many diseases, expression and ligand-dependent activity of the p75NTR receptor can
promote pericyte and vascular dysfunction, inflammation, glial activation, and …