The present review paper focuses on the chemistry of oxidative stress mitigation by
antioxidants. Oxidative stress is understood as a lack of balance between the pro-oxidant …

Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …

Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Metastatic disease is the leading cause of cancer-related deaths and involves critical
interactions between tumor cells and the microenvironment. Hypoxia is a potent …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Since the initial identification of the novel coronavirus SARS-CoV-2 in December 2019, the
COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As …