Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Neuronal computation is energetically expensive. Consequently, the brain's limited energy
supply imposes constraints on its information processing capability. Most brain energy is …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or
extrinsic stimuli by reorganizing its structure, function and connections. Major advances in …

Type 2 diabetes mellitus (T2DM) is a complex, chronic and progressive metabolic disease,
which is characterized by relative insulin deficiency, insulin resistance, and high glucose …

When administered either systemically or centrally, glucose is a potent enhancer of memory
processes. Measures of glucose levels in extracellular fluid in the rat hippocampus during …

Synaptic plasticity confers environmental adaptability through modification of the
connectivity between neurons and neuronal circuits. This is achieved through changes to …

The aim of the present study was to analyze the action of metformin on short-term memory,
glial cell activation and neuroinflammation caused by experimental diabetic encephalopathy …

Background Metformin, a first-line antiglycemic drug, has been reported to have anti-
depressant effects in patients with type 2 diabetes; however, its exact role and underlying …

AIM: Metformin is a first line drug for the treatment of type 2 diabetes mellitus (T2DM). Our
previous study reported that high-fat diet (HFD) consumption caused not only peripheral and …