Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …

Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high
mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and …

Malaria has had a major effect on the human genome, with many protective polymorphisms—
such as the sickle-cell trait—having been selected to high frequencies in malaria-endemic …

Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …

The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

The human genetic factors that affect resistance to infectious disease are poorly understood.
Here we report a genome-wide association study in 17,000 severe malaria cases and …

Severe malaria caused by Plasmodium falciparum is difficult to diagnose accurately in
children in high-transmission settings. Using data from 2649 pediatric and adult patients …

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

As the most prevalent aboriginal group on Hainan Island located between South China and
the mainland of Southeast Asia, the Li people are believed to preserve some unique genetic …

Glycophorins are heavily glycosylated sialoglycoproteins of human and animal erythrocytes.
In humans, there are four glycophorins: A, B, C and D. Glycophorins play an important role in …