Centrosomes, which were first described in the late 19th century, are found in most animal
cells and undergo duplication once every cell cycle so that their number remains stable, like …

Intense research over the past four years has led to the discovery and characterization of a
novel signalling network, known as the Salvador–Warts–Hippo (SWH) pathway, involved in …

Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. New
techniques, including the application of small-molecule inhibitors, have greatly expanded …

The “Hippo” signaling pathway has emerged as a major regulator of cell proliferation and
survival in metazoans. The pathway, as delineated by genetic and biochemical studies in …

The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …

The use of fungal model systems, such as Saccharomyces cerevisisae and
Schizosaccharomyces pombe, has contributed enormously to our understanding of …

In both animal cells and fungi, cytokinesis proceeds via a contractile actomyosin ring (CAR).
Many CAR components and regulators are evolutionarily conserved. In …

The Ase1/Prc1 proteins constitute a conserved microtubule-associated protein family that is
implicated in central spindle formation and cytokinesis. Here we characterize a role for …

Schizosaccharomyces pombe contains four putative (1, 3) β-D-glucan synthase (GS)
catalytic subunits, Bgs1p-4p. In this work, we cloned bgs4+ and show that Bgs4p is the only …

Cytokinesis is a crucial event in the cell cycle of all living cells. In fungal cells, it requires co‐
ordinated contraction of an actomyosin ring and synthesis of both plasmatic membrane and …