Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple
brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining …

The complexity of many cellular and organismal traits results from the integration of genetic
and environmental factors via molecular networks. Network structure and effect propagation …

Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to
generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks …

Most age-related neurodegenerative diseases remain incurable owing to an incomplete
understanding of the disease mechanisms. Several environmental and genetic factors …

The concept of the ischemic penumbra was originally defined as the area around a necrotic
stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra …

The DNA damage response (DDR) plays crucial roles in cancer prevention and therapy.
Poly (ADP-ribose) polymerase 1 (PARP1) mediates multiple signal transduction in the DDR …

Abstract Background and Objective Metabolomics studies of recreational and elite athletes
have been so far limited to venipuncture-dependent blood sample collection in the setting of …