Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

The ribotoxic stress response (RSR) is a signaling pathway in which the p38-and c-Jun N-
terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) …

Impairment of translation can lead to collisions of ribosomes, which constitute an activation
platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic …

Impairment of protein translation can cause stalling and collision of ribosomes and is a
signal for the activation of ribosomal surveillance and rescue pathways. Despite clear …

Oxidative stress modulates carcinogenesis in the liver; however, direct evidence for
metabolic control of oxidative stress during pathogenesis, particularly, of progression from …

Transaldolase deficiency predisposes to chronic liver disease progressing from cirrhosis to
hepatocellular carcinoma (HCC). Transition from cirrhosis to hepatocarcinogenesis depends …

Stem cells in their natural microenvironment are exposed to biochemical and biophysical
cues emerging from the extracellular matrix (ECM) and neighboring cells. In particular …

A conditional knock-in mouse was generated in which the TAK1 catalytic subunit was largely
replaced by the kinase-inactive TAK1 [D175A] mutant in immune cells. The activation of …

The ZAK gene encodes two functionally distinct kinases, ZAKα and ZAKβ. Homozygous loss
of function mutations affecting both isoforms causes a congenital muscle disease. ZAKβ is …