Leprosy is caused by Mycobacterium leprae and has been known since biblical times. It is
still endemic in many regions of the world and a public health problem in Brazil. The …

Leprosy is a granulomatous disease affecting the skin and nerves caused by Mycobacterium
leprae. It continues to be a significant public health problem. Multidrug therapy (MDT) cures …

Despite the availability of effective treatment for several decades, leprosy remains an
important medical problem in many regions of the world. Infection with Mycobacterium …

Leprosy is an infectious disease caused by the obligate intracellular pathogen
Mycobacterium leprae and remains endemic in many parts of the world. Despite several …

The past few years have been very productive concerning the identification of genes
associated with leprosy. Candidate gene strategies using both case–control and family …

Susceptibility to infectious diseases is influenced by genetic background and efficient
cellular immune activation is responsible for protection. In tuberculosis (TB), interferon …

Investigation into the innate immune response in leprosy has provided insight into
immunoregulation in human infectious disease. Key advances include the role of pattern …

In this review, we discuss recently accumulated data, analysing genetic influence on leprosy
outcome. Most leprosy-related epidemiological studies are based on the comparison of …

Increased production of IL-10 has been frequently associated with augmented susceptibility
to infection. However, the correlation between IL-10 activity and susceptibility to …

Genetics plays a crucial role in controlling susceptibility to infectious diseases by modulating
the interplay between humans and pathogens. This is particularly evident in leprosy, since …