L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …

One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …

Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

Human breast tumours are diverse in their natural history and in their responsiveness to
treatments. Variation in transcriptional programs accounts for much of the biological diversity …

The leukocyte Fcγ receptor (FcγR)-mediated response is important for the efficacy of
therapeutic antibodies; however, little is known about the role of FcγRs in other cell types …

Mast cell mediator release represents a pivotal event in the initiation of inflammatory
reactions associated with allergic disorders. These responses follow antigen‐mediated …

Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated
by Rac small guanine nucleotide-binding proteins. Vav, a guanosine diphosphate (GDP) …

The GTP hydrolases of the Rho/Rac family participate in the generation of coordinated
cellular responses to extracellular stimuli (52, 153). Their actions are essential to promote …

Syk is a protein tyrosine kinase that is widely expressed in haematopoietic cells. It is
involved in coupling activated immunoreceptors to downstream signalling events that …