Background The poor physical health of people with mental illness is a multifaceted,
transdiagnostic, and global problem. People with mental illness have an increased risk of …

Background Antipsychotic treatment is associated with metabolic disturbance. However, the
degree to which metabolic alterations occur in treatment with different antipsychotics is …

People with schizophrenia die 15‐20 years prematurely. Understanding mortality risk and
aggravating/attenuating factors is essential to reduce this gap. We conducted a systematic …

Psychiatric patients have a greater risk of premature mortality, predominantly due to
cardiovascular diseases (CVDs). Convincing evidence shows that psychiatric conditions are …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Importance Schizophrenia is associated with alterations in mean regional brain volumes.
However, it is not known whether the clinical heterogeneity seen in the disorder is reflected …

Abstract Purpose of Review The prevalence of diabetes is 2–3-fold higher in people with
severe mental illness than the general population. There are concerns that antipsychotics …

The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with
conflicting results. An umbrella review of meta-analyses of non-genetic peripheral …

Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia
because of their high clinical efficacy. However, SGA treatment is associated with severe …