Abstract Objective N6-Methyladenosine (m6A) is the most common RNA modification in
eukaryotic mRNAs and growing evidence suggests that m6A modification and its regulators …

Simple Summary Cancers in the head and neck region are often aggressive and poorly
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …

Small proline-rich proteins (SPRRPs) are traditionally known for their function in keratinocyte
homeostasis. Recent evidence demonstrates their involvement in additional diverse …

Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma
skin cancer characterized by high invasiveness, heterogeneity, and mainly occurs in the …

Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly heterogeneous group of
tumors characterized by an incidence of 650,000 new cases and 350,000 deaths per year …

TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein
of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in …

Background Emerging research has identified the N6‐methyladenosine (m6A) modification
and its regulatory enzymes, including methyltransferase 5 (METTL5), as critical players in …

Background Laryngeal squamous cell carcinomas (LSCCs) have a high risk of recurrence
and poor prognosis. Patient‐derived cancer cell lines remain important preclinical models …

Understanding the genomic alterations in oral carcinogenesis remains crucial for the
appropriate diagnosis and treatment of oral squamous cell carcinoma (OSCC). To unveil the …

Genomic analyses of head and neck squamous cell carcinoma (HNSCC) have highlighted
alterations in the phosphatidylinositol 3-kinase (PI3K) signaling pathway, presenting a …