RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside

M Ratti, A Lampis, M Ghidini, M Salati, MB Mirchev… - Targeted …, 2020 - Springer
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

VS Peche, TA Pietka, M Jacome-Sosa… - Nature …, 2023 - nature.com
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

The functional organization of axonal mRNA transport and translation

I Dalla Costa, CN Buchanan, MD Zdradzinski… - Nature Reviews …, 2021 - nature.com
Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

OG de Jong, DE Murphy, I Mäger, E Willms… - Nature …, 2020 - nature.com
Extracellular vesicles (EVs) form an endogenous transport system for intercellular transfer of
biological cargo, including RNA, that plays a pivotal role in physiological and pathological …

Unpacking extracellular vesicles: RNA cargo loading and function

ER Dellar, C Hill, GE Melling… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are a heterogeneous group of membrane‐enclosed structures
produced by prokaryotic and eukaryotic cells. EVs carry a range of biological cargoes …

An RNA exosome subunit mediates cell-to-cell trafficking of a homeobox mRNA via plasmodesmata

M Kitagawa, P Wu, R Balkunde, P Cunniff, D Jackson - Science, 2022 - science.org
Messenger RNAs (mRNAs) function as mobile signals for cell-to-cell communication in
multicellular organisms. The KNOTTED1 (KN1) homeodomain family transcription factors act …

Transzonal projections: Essential structures mediating intercellular communication in the mammalian ovarian follicle

HJ Clarke - Molecular Reproduction and Development, 2022 - Wiley Online Library
The development of germ cells relies on contact and communication with neighboring
somatic cells that provide metabolic support and regulatory signals. In females, contact is …

Nanotube‐like processes facilitate material transfer between photoreceptors

AA Kalargyrou, M Basche, A Hare, EL West… - EMBO …, 2021 - embopress.org
Neuronal communication is typically mediated via synapses and gap junctions. New forms
of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs) …

Avidity-based bright and photostable light-up aptamers for single-molecule mRNA imaging

B Bühler, J Schokolowski, A Benderoth… - Nature Chemical …, 2023 - nature.com
Fluorescent light-up aptamers (FLAPs) have emerged as valuable tools to visualize RNAs,
but are mostly limited by their poor brightness, low photostability, and high fluorescence …