RNA delivery by extracellular vesicles in mammalian cells and its applications
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside
M Ratti, A Lampis, M Ghidini, M Salati, MB Mirchev… - Targeted …, 2020 - Springer
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …
been considered as 'junk'for a long time, non-coding RNAs are now well established as …
Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
The functional organization of axonal mRNA transport and translation
I Dalla Costa, CN Buchanan, MD Zdradzinski… - Nature Reviews …, 2021 - nature.com
Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …
localized mRNA translation to rapidly respond to different extracellular stimuli and …
A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA
Extracellular vesicles (EVs) form an endogenous transport system for intercellular transfer of
biological cargo, including RNA, that plays a pivotal role in physiological and pathological …
biological cargo, including RNA, that plays a pivotal role in physiological and pathological …
Unpacking extracellular vesicles: RNA cargo loading and function
Extracellular vesicles (EVs) are a heterogeneous group of membrane‐enclosed structures
produced by prokaryotic and eukaryotic cells. EVs carry a range of biological cargoes …
produced by prokaryotic and eukaryotic cells. EVs carry a range of biological cargoes …
An RNA exosome subunit mediates cell-to-cell trafficking of a homeobox mRNA via plasmodesmata
M Kitagawa, P Wu, R Balkunde, P Cunniff, D Jackson - Science, 2022 - science.org
Messenger RNAs (mRNAs) function as mobile signals for cell-to-cell communication in
multicellular organisms. The KNOTTED1 (KN1) homeodomain family transcription factors act …
multicellular organisms. The KNOTTED1 (KN1) homeodomain family transcription factors act …
Transzonal projections: Essential structures mediating intercellular communication in the mammalian ovarian follicle
HJ Clarke - Molecular Reproduction and Development, 2022 - Wiley Online Library
The development of germ cells relies on contact and communication with neighboring
somatic cells that provide metabolic support and regulatory signals. In females, contact is …
somatic cells that provide metabolic support and regulatory signals. In females, contact is …
Nanotube‐like processes facilitate material transfer between photoreceptors
AA Kalargyrou, M Basche, A Hare, EL West… - EMBO …, 2021 - embopress.org
Neuronal communication is typically mediated via synapses and gap junctions. New forms
of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs) …
of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs) …
Avidity-based bright and photostable light-up aptamers for single-molecule mRNA imaging
B Bühler, J Schokolowski, A Benderoth… - Nature Chemical …, 2023 - nature.com
Fluorescent light-up aptamers (FLAPs) have emerged as valuable tools to visualize RNAs,
but are mostly limited by their poor brightness, low photostability, and high fluorescence …
but are mostly limited by their poor brightness, low photostability, and high fluorescence …