The atomic force microscope (AFM) is not only a tool to image the topography of solid
surfaces at high resolution. It can also be used to measure force-versus-distance curves …

For the identification of nucleic acids, which are important biomarkers of pathogen-mediated
diseases and viruses, the gold standard for NA-based diagnostic applications is polymerase …

The interaction of Rebeccamycin with calf thymus (ctDNA) in the absence and presence of
H1 was investigated by molecular dynamics, multi-spectroscopic, and cellular techniques …

Summary 2′, 3′-cAMP is a positional isomer of the well-established second messenger
3′, 5′-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide …

Loop-mediated isothermal amplification (LAMP) as a diagnostic tool is rapidly gaining
recognition and maturity. Among various advantages over traditional polymerase chain …

SYBR Gold is a commonly used and particularly bright fluorescent DNA stain, however, its
chemical structure is unknown and its binding mode to DNA remains controversial. Here, we …

Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …

Mechanical properties of single double-stranded DNA (dsDNA) in the presence of different
binding ligands were analyzed in optical-tweezers experiments with subpiconewton force …

We have designed a PEGylated LPD (liposome-polycation-DNA) nanoparticle for systemic,
specific, and efficient delivery of small interfering RNA (siRNA) into solid tumors in mice by …

Chemoresistance and hence the consequent treatment failure is considerably challenging in
clinical cancer therapeutics. The understanding of the genetic variations in chemoresistance …