Deconstructing the antiviral neutralizing-antibody response: implications for vaccine development and immunity

LA VanBlargan, L Goo, TC Pierson - Microbiology and Molecular …, 2016 - Am Soc Microbiol
The antibody response plays a key role in protection against viral infections. While antiviral
antibodies may reduce the viral burden via several mechanisms, the ability to directly inhibit …

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

K Stettler, M Beltramello, DA Espinosa, V Graham… - Science, 2016 - science.org
Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has
become a public health emergency. By characterizing memory lymphocytes from ZIKV …

Dengue virus antibodies enhance Zika virus infection

LM Paul, ER Carlin, MM Jenkins, AL Tan… - Clinical & …, 2016 - Wiley Online Library
For decades, human infections with Zika virus (ZIKV), a mosquito‐transmitted flavivirus, were
sporadic, associated with mild disease, and went underreported since symptoms were …

The development of therapeutic antibodies against dengue virus

G Fibriansah, SM Lok - Antiviral research, 2016 - Elsevier
Dengue virus, a positive-sense RNA virus, is one of the major human pathogens transmitted
by mosquitoes. However, no fully effective licensed dengue vaccines or therapeutics are …

[HTML][HTML] Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera

R De Alwis, KL Williams, MA Schmid, CY Lai… - PLoS …, 2014 - journals.plos.org
Dengue viruses (DENV) are mosquito-borne flaviviruses of global importance. DENV exist
as four serotypes, DENV1-DENV4. Following a primary infection, individuals produce DENV …

[HTML][HTML] Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice

M Yang, H Lai, H Sun, Q Chen - Scientific reports, 2017 - nature.com
Several Zika virus (ZIKV) vaccine candidates have recently been described which use
inactivated whole virus, DNA or RNA that express the virus' Envelope (E) glycoprotein as the …

Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus

M Yang, M Dent, H Lai, H Sun, Q Chen - Vaccine, 2017 - Elsevier
In this study, we described the generation and immunogenicity of the Zika Virus (ZIKV)
envelope protein (E) domain III (DIII) as a protein subunit vaccine candidate. ZIKV EDIII …

The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the …

SA Smith, AR de Alwis, N Kose, E Harris, KD Ibarra… - MBio, 2013 - Am Soc Microbiol
Following natural dengue virus (DENV) infection, humans produce some antibodies that
recognize only the serotype of infection (type specific) and others that cross-react with all …

Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies

ST Kudlacek, S Metz, D Thiono, AM Payne… - Science …, 2021 - science.org
Dengue virus (DENV) is a worldwide health burden, and a safe vaccine is needed.
Neutralizing antibodies bind to quaternary epitopes on DENV envelope (E) protein …

High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection

WY Tsai, CY Lai, YC Wu, HE Lin, C Edwards… - Journal of …, 2013 - Am Soc Microbiol
The envelope (E) protein of dengue virus (DENV) is the major target of neutralizing
antibodies (Abs) and vaccine development. Previous studies of human dengue-immune …