Deconstructing the antiviral neutralizing-antibody response: implications for vaccine development and immunity
LA VanBlargan, L Goo, TC Pierson - Microbiology and Molecular …, 2016 - Am Soc Microbiol
The antibody response plays a key role in protection against viral infections. While antiviral
antibodies may reduce the viral burden via several mechanisms, the ability to directly inhibit …
antibodies may reduce the viral burden via several mechanisms, the ability to directly inhibit …
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
K Stettler, M Beltramello, DA Espinosa, V Graham… - Science, 2016 - science.org
Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has
become a public health emergency. By characterizing memory lymphocytes from ZIKV …
become a public health emergency. By characterizing memory lymphocytes from ZIKV …
Dengue virus antibodies enhance Zika virus infection
LM Paul, ER Carlin, MM Jenkins, AL Tan… - Clinical & …, 2016 - Wiley Online Library
For decades, human infections with Zika virus (ZIKV), a mosquito‐transmitted flavivirus, were
sporadic, associated with mild disease, and went underreported since symptoms were …
sporadic, associated with mild disease, and went underreported since symptoms were …
The development of therapeutic antibodies against dengue virus
G Fibriansah, SM Lok - Antiviral research, 2016 - Elsevier
Dengue virus, a positive-sense RNA virus, is one of the major human pathogens transmitted
by mosquitoes. However, no fully effective licensed dengue vaccines or therapeutics are …
by mosquitoes. However, no fully effective licensed dengue vaccines or therapeutics are …
[HTML][HTML] Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera
R De Alwis, KL Williams, MA Schmid, CY Lai… - PLoS …, 2014 - journals.plos.org
Dengue viruses (DENV) are mosquito-borne flaviviruses of global importance. DENV exist
as four serotypes, DENV1-DENV4. Following a primary infection, individuals produce DENV …
as four serotypes, DENV1-DENV4. Following a primary infection, individuals produce DENV …
[HTML][HTML] Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice
Several Zika virus (ZIKV) vaccine candidates have recently been described which use
inactivated whole virus, DNA or RNA that express the virus' Envelope (E) glycoprotein as the …
inactivated whole virus, DNA or RNA that express the virus' Envelope (E) glycoprotein as the …
Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus
In this study, we described the generation and immunogenicity of the Zika Virus (ZIKV)
envelope protein (E) domain III (DIII) as a protein subunit vaccine candidate. ZIKV EDIII …
envelope protein (E) domain III (DIII) as a protein subunit vaccine candidate. ZIKV EDIII …
The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the …
SA Smith, AR de Alwis, N Kose, E Harris, KD Ibarra… - MBio, 2013 - Am Soc Microbiol
Following natural dengue virus (DENV) infection, humans produce some antibodies that
recognize only the serotype of infection (type specific) and others that cross-react with all …
recognize only the serotype of infection (type specific) and others that cross-react with all …
Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies
Dengue virus (DENV) is a worldwide health burden, and a safe vaccine is needed.
Neutralizing antibodies bind to quaternary epitopes on DENV envelope (E) protein …
Neutralizing antibodies bind to quaternary epitopes on DENV envelope (E) protein …
High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection
WY Tsai, CY Lai, YC Wu, HE Lin, C Edwards… - Journal of …, 2013 - Am Soc Microbiol
The envelope (E) protein of dengue virus (DENV) is the major target of neutralizing
antibodies (Abs) and vaccine development. Previous studies of human dengue-immune …
antibodies (Abs) and vaccine development. Previous studies of human dengue-immune …