Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

The interest in 3, 4-dihydropyrimidine-2 (1 H)-(thio) ones is increasing every day, mainly due
to their paramount biological relevance. The Biginelli reaction is the classical approach to …

The reactivity of aldehydes and ketones carries great potential for multicomponent
heterocyclizations. These reactions are convergent and highly versatile in the development …

Chiral phosphorous-containing compounds are playing a more and more significant role in
several different research fields. Here, we show a chiral phosphoric acid-catalyzed …

The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century,
due to the pharmacological application of its products. This review focuses predominantly on …

Various catalytic and non-catalytic organic transformations are carried out in glycerol media
with superior efficiency over commonly employed organic solvents. The success of glycerol …

A chiral spirocyclic phosphoric acid‐catalyzed asymmetric Biginelli reaction based on
aliphatic aldehydes has been realized for the synthesis of biologically important and …

5-Substituted (1, 3-thiazolidin-2-ylidene) ketones react regioselectively with 1-chlorobenzyl
isocyanates under mild conditions to form diastereomeric 8-acyl-2, 3, 6, 7-tetrahydro-5 H-[1 …

(+)-Crambescin A belongs to the polycyclic guanidine natural product family and has been
shown to possess various medically important properties. The chiral bicyclic guanidine …

Background: We found in the literature, an excellent review of the Biginelli reaction that
addresses the methodologies for obtaining enantiopure dihydropyrimidinones (DHPMs). In …