Metabolic interactions in the tumor microenvironment
CA Lyssiotis, AC Kimmelman - Trends in cell biology, 2017 - cell.com
Tumors are dynamic pseudoorgans that contain numerous cell types interacting to create a
unique physiology. Within this network, the malignant cells encounter many challenges and …
unique physiology. Within this network, the malignant cells encounter many challenges and …
Obesity, inflammation, and cancer
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including cancer, and is increasingly recognized as a growing cause of preventable cancer …
including cancer, and is increasingly recognized as a growing cause of preventable cancer …
Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy
It remains unclear how obesity worsens treatment outcomes in patients with pancreatic
ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and …
ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and …
The role of adiponectin in cancer: a review of current evidence
M Dalamaga, KN Diakopoulos… - Endocrine …, 2012 - academic.oup.com
Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …
[HTML][HTML] Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview
A Banerjee, S Mukherjee, BK Maji - Toxicology Reports, 2021 - Elsevier
In this fast-food era, people depend on ready-made foods and engage in minimal physical
activities that ultimately change their food habits. Majorities of such foods have harmful …
activities that ultimately change their food habits. Majorities of such foods have harmful …
Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2
J Incio, JA Ligibel, DT McManus, P Suboj… - Science translational …, 2018 - science.org
Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in
patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy …
patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy …
The clinical significance of pancreatic steatosis
MM Smits, EJM Van Geenen - Nature reviews Gastroenterology & …, 2011 - nature.com
More research is now focused on pancreatic steatosis. Multiple definitions, clinical
associations and synonyms for pancreatic steatosis are described in the literature and can …
associations and synonyms for pancreatic steatosis are described in the literature and can …
Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN)
V Rebours, S Gaujoux, G d'Assignies, A Sauvanet… - Clinical Cancer …, 2015 - AACR
Purpose: The roles of intravisceral and subcutaneous fat are unknown, and the prevalence
of precancerous lesions in obese patients was never evaluated. This study aims to assess …
of precancerous lesions in obese patients was never evaluated. This study aims to assess …
Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms
PM Bracci - Molecular carcinogenesis, 2012 - Wiley Online Library
Abstract In the United States, pancreatic cancer is characterized by a low 5‐yr survival rate
of approximately 6%, fewer than 10% of patients diagnosed with localized disease and thus …
of approximately 6%, fewer than 10% of patients diagnosed with localized disease and thus …
Molecular pathways: adiponectin and leptin signaling in cancer
MN VanSaun - Clinical Cancer Research, 2013 - AACR
The increasing percentage of obese individuals in the population and its independent
association of increased risk for the development of cancer have heightened the necessity to …
association of increased risk for the development of cancer have heightened the necessity to …