Metabolic interactions in the tumor microenvironment

CA Lyssiotis, AC Kimmelman - Trends in cell biology, 2017 - cell.com
Tumors are dynamic pseudoorgans that contain numerous cell types interacting to create a
unique physiology. Within this network, the malignant cells encounter many challenges and …

Obesity, inflammation, and cancer

T Deng, CJ Lyon, S Bergin, MA Caligiuri… - Annual Review of …, 2016 - annualreviews.org
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including cancer, and is increasingly recognized as a growing cause of preventable cancer …

Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy

J Incio, H Liu, P Suboj, SM Chin, IX Chen, M Pinter… - Cancer discovery, 2016 - AACR
It remains unclear how obesity worsens treatment outcomes in patients with pancreatic
ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and …

The role of adiponectin in cancer: a review of current evidence

M Dalamaga, KN Diakopoulos… - Endocrine …, 2012 - academic.oup.com
Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

[HTML][HTML] Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview

A Banerjee, S Mukherjee, BK Maji - Toxicology Reports, 2021 - Elsevier
In this fast-food era, people depend on ready-made foods and engage in minimal physical
activities that ultimately change their food habits. Majorities of such foods have harmful …

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

J Incio, JA Ligibel, DT McManus, P Suboj… - Science translational …, 2018 - science.org
Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in
patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy …

The clinical significance of pancreatic steatosis

MM Smits, EJM Van Geenen - Nature reviews Gastroenterology & …, 2011 - nature.com
More research is now focused on pancreatic steatosis. Multiple definitions, clinical
associations and synonyms for pancreatic steatosis are described in the literature and can …

Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN)

V Rebours, S Gaujoux, G d'Assignies, A Sauvanet… - Clinical Cancer …, 2015 - AACR
Purpose: The roles of intravisceral and subcutaneous fat are unknown, and the prevalence
of precancerous lesions in obese patients was never evaluated. This study aims to assess …

Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms

PM Bracci - Molecular carcinogenesis, 2012 - Wiley Online Library
Abstract In the United States, pancreatic cancer is characterized by a low 5‐yr survival rate
of approximately 6%, fewer than 10% of patients diagnosed with localized disease and thus …

Molecular pathways: adiponectin and leptin signaling in cancer

MN VanSaun - Clinical Cancer Research, 2013 - AACR
The increasing percentage of obese individuals in the population and its independent
association of increased risk for the development of cancer have heightened the necessity to …