Synergy and antagonism in natural product extracts: when 1+ 1 does not equal 2

LK Caesar, NB Cech - Natural product reports, 2019 - pubs.rsc.org
Covering: 2000 to 2019 According to a 2012 survey from the Centers for Disease Control
and Prevention, approximately 18% of the US population uses natural products (including …

Interactions between natural products—A review

N Rajčević, D Bukvički, T Dodoš, PD Marin - Metabolites, 2022 - mdpi.com
Plant-based natural products have been used as a source for therapeutics since the dawn of
civilization. According to the World Health Organization (WHO), more than 80% of the …

Network-based modeling of herb combinations in traditional Chinese medicine

Y Wang, H Yang, L Chen, M Jafari… - Briefings in …, 2021 - academic.oup.com
Traditional Chinese medicine (TCM) has been practiced for thousands of years for treating
human diseases. In comparison to modern medicine, one of the advantages of TCM is the …

Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer

L Zhang, Y Xiao, R Yang, S Wang, SX Ma, J Liu… - Scientific Reports, 2021 - nature.com
Because of the complex etiology, the treatment of gastric cancer is a formidable challenge
for contemporary medical. The current treatment method focuses on traditional surgical …

Network Pharmacology-Based Strategy for the Investigation of the Anti-Obesity Effects of an Ethanolic Extract of Zanthoxylum bungeanum Maxim

Y Wang, SH Yang, K Zhong, T Jiang… - Frontiers in …, 2020 - frontiersin.org
Network pharmacology is considered as the next paradigm in drug discovery. In an era
when obesity has become global epidemic, network pharmacology becomes an ideal tool to …

Systematic elucidation of the mechanism of genistein against pulmonary hypertension via network pharmacology approach

Y Chen, D Chen, S Liu, T Yuan, J Guo, L Fang… - International Journal of …, 2019 - mdpi.com
Numerous studies have shown that genistein has a good therapeutic effect on pulmonary
hypertension (PH). However, there has been no systematic research performed yet to …

A novel strategy for decoding and validating the combination principles of huanglian jiedu decoction from multi-scale perspective

KX Wang, Y Gao, WX Gong, XF Ye, LY Fan… - Frontiers in …, 2020 - frontiersin.org
Traditional Chinese medicine (TCM) formulas treat complex diseases through combined
botanical drugs which follow specific compatibility rules to reduce toxicity and increase …

Exploring the protective effects and mechanism of crocetin from saffron against NAFLD by network pharmacology and experimental validation

Z Xu, S Lin, J Gong, P Feng, Y Cao, Q Li, Y Jiang… - Frontiers in …, 2021 - frontiersin.org
Background: Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem but
no drug has been approved for its treatment. Animal experiments and clinical trials have …

A network pharmacology study on the molecular mechanisms of FDY003 for breast cancer treatment

HS Lee, IH Lee, K Kang, SI Park… - Evidence‐Based …, 2021 - Wiley Online Library
Herbal medicines have drawn considerable attention with regard to their potential
applications in breast cancer (BC) treatment, a frequently diagnosed malignant disease …

Crude polysaccharide from a wild mushroom enhances immune response in murine macrophage cells by TLR/NF-κB pathway

S Ghosh, S Khatua, K Acharya - Journal of Pharmacy and …, 2019 - academic.oup.com
Objective Mushroom crude polysaccharides offer a complete package of various medicinal
activities. In this context, the present study aimed to unveil structural and biomedical …