The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is
rapidly increasing worldwide at an alarming pace, due to an increase in obesity, sedentary …

Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options,
novel therapies are desperately needed. Recent studies have shown that GBM acquires …

Lipid metabolism reprogramming is an important hallmark of tumor progression. Cancer
cells require high levels of lipid synthesis and uptake not only to support their continued …

In mammals, O2 and CO2 levels are tightly regulated and are altered under various
pathological conditions. While the molecular mechanisms that participate in O2 sensing are …

High-risk neuroblastoma exhibits transcriptional activation of the mevalonate pathway that
produces cholesterol and nonsterol isoprenoids. A better understanding of how this …

Bile salt hydrolase (BSH)-producing bacteria are negatively related to the body weight gain
and energy storage of the host. We aimed to obtain a novel BSH-producing strain with …

The metabolic and signaling pathways regulating aggressive mesenchymal colorectal
cancer (CRC) initiation and progression through the serrated route are largely unknown …

Lipid synthesis is regulated by the actions of Scap, a polytopic membrane protein that binds
cholesterol in membranes of the endoplasmic reticulum (ER). When ER cholesterol levels …

Sterol regulatory element-binding protein (SREBP) transcription factors are central
regulators of lipid homeostasis and are essential for lipid metabolic reprogramming that …

The phenomenon of polypharmacy is a common occurrence among older people with
multiple health conditions due to the rapid increase in population aging and the …