Classical dendritic cells (cDCs) form a critical interface between innate and adaptive
immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of …

Immune cell populations in the skin are predominantly comprised of dendritic cells (DCs)
and macrophages. A lack of consensus regarding how to define these cell types has …

Dendritic cells (DCs) are cells derived from the hematopoietic stem cells (HSCs) of the bone
marrow and form a widely distributed cellular system throughout the body. They are the most …

Highlights•cDCs, pDCs and monocytes arise from distinct developmental intermediates.•
Lineage affiliation by ontogeny provides a robust means of cell classification.•Transcriptional …

Granulocytes, monocytes, macrophages, and dendritic cells (DCs) represent a subgroup of
leukocytes, collectively called myeloid cells. During the embryonic development of …

Glycosylceramides in mammalian species are thought to be present in the form of β-
anomers. This conclusion was reinforced by the identification of only one glucosylceramide …

Invariant natural killer T (iNKT) cells are a unique population of T lymphocytes, which lie at
the interface between the innate and adaptive immune systems, and are important …

In a structure-function study of sulfatides that typically stimulate type II NKT cells, we made
an unexpected discovery. We compared analogs with sphingosine or phytosphingosine …

Innate immune mechanisms play an important role in inflammatory chronic liver diseases. In
this study, we investigated the role of type I or invariant NKT (iNKT) cell subsets in the …

Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid
antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells …