Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

S Frantz, MJ Hundertmark… - European heart …, 2022 - academic.oup.com
Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

[HTML][HTML] Treatment strategies of acute myocardial infarction: updates on revascularization, pharmacological therapy, and beyond

Y Saito, K Oyama, K Tsujita, S Yasuda, Y Kobayashi - Journal of cardiology, 2023 - Elsevier
Owing to recent advances in early reperfusion strategies, pharmacological therapy,
standardized care, and the identification of vulnerable patient subsets, the prognosis of …

Impact of sacubitril/valsartan compared with ramipril on cardiac structure and function after acute myocardial infarction: the PARADISE-MI echocardiographic substudy

AM Shah, B Claggett, N Prasad, G Li, M Volquez… - Circulation, 2022 - Am Heart Assoc
Background: Angiotensin-converting enzyme inhibitors attenuate left ventricular (LV)
enlargement after acute myocardial infarction (AMI). Preclinical data suggest similar benefits …

A pragmatic randomized feasibility trial of influenza vaccines

ND Johansen, D Modin, J Nealon, S Samson… - NEJM …, 2023 - evidence.nejm.org
Background The relative vaccine effectiveness (rVE) of high-dose quadrivalent influenza
vaccines (QIV-HD) versus standard-dose quadrivalent influenza vaccines (QIV-SD) against …

Declining risk of heart failure hospitalization following first acute myocardial infarction in Scotland between 1991–2016

KF Docherty, AM Jackson, M Macartney… - European Journal of …, 2023 - Wiley Online Library
Aim Mortality from acute myocardial infarction (AMI) has declined, increasing the pool of
survivors at risk of later development of heart failure (HF). However, coronary reperfusion …

Sacubitril/valsartan in heart failure: efficacy and safety in and outside clinical trials

A Abdin, M Schulz, U Riemer, B Hadëri… - ESC heart …, 2022 - Wiley Online Library
Heart failure (HF) treatment has changed substantially over the last 30 years, leading to
significant reductions in mortality and hospital admissions in patients with HF with reduced …

Sacubitril/valsartan versus ramipril for patients with acute myocardial infarction: win‐ratio analysis of the PARADISE‐MI trial

O Berwanger, M Pfeffer, B Claggett… - European journal of …, 2022 - Wiley Online Library
Aim The win ratio can incorporate different types of outcomes and enhance statistical power,
making it a useful method for analysing composite outcomes in cardiovascular trials. The …

Quantifying treatment effects in trials with multiple event-time outcomes

BL Claggett, ZR McCaw, L Tian, JJV McMurray… - NEJM …, 2022 - evidence.nejm.org
Background Data on the occurrence times of multiple outcomes, reflecting the temporal
profile of disease burden/progression, have been used to estimate treatment effects in …

The effects of angiotensin receptor-neprilysin inhibition on major coronary events in patients with acute myocardial infarction: insights from the PARADISE-MI trial

R Mehran, PG Steg, MA Pfeffer, K Jering, B Claggett… - Circulation, 2022 - Am Heart Assoc
Background: In patients who survive an acute myocardial infarction (AMI), angiotensin-
converting enzyme inhibitors decrease the risk of subsequent major cardiovascular events …

Feasibility of randomizing Danish citizens aged 65–79 years to high-dose quadrivalent influenza vaccine vs. standard-dose quadrivalent influenza vaccine in a …

ND Johansen, D Modin, J Nealon, S Samson… - Pilot and Feasibility …, 2022 - Springer
Background High-dose influenza vaccines provide better protection against influenza
infection than standard-dose in persons aged 65 years and above; however, in most …