The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …

The field of Alzheimer's disease (AD) research has grown exponentially over the past few
decades, especially since the isolation and identification of amyloid-β from postmortem …

The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid
plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and …

Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

The development of atomic force microscopy (AFM) has opened up a wide range of novel
opportunities in nanoscience and new modalities of observation in complex biological …

Atomic force microscopy (AFM) is an easy‐to‐use, powerful, high‐resolution microscope that
allows the user to image any surface and under any aqueous condition. AFM has been used …

As the population across the globe continues to dramatically increase, the prevalence of
cognitive impairment and dementia will inevitably increase as well, placing increasing …

It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …