MSC exosome works through a protein-based mechanism of action

WS Toh, RC Lai, B Zhang, SK Lim - Biochemical Society …, 2018 - portlandpress.com
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …

MicroRNAs in the pathogenesis of hepatocellular carcinoma: A review

A Morishita, K Oura, T Tadokoro, K Fujita, J Tani… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is one of the most frequently occurring
cancers, and the prognosis for late-stage HCC remains poor. A better understanding of the …

[HTML][HTML] The role of MicroRNAs in hepatocellular carcinoma

X Xu, Y Tao, L Shan, R Chen, H Jiang, Z Qian… - Journal of …, 2018 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common cancers, leading to the second
cancer-related death in the global. Although the treatment of HCC has greatly improved over …

Hepatic stellate cells and microRNAs in pathogenesis of liver fibrosis

M Kitano, PM Bloomston - Journal of clinical medicine, 2016 - mdpi.com
microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either
blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in …

Targeting long non-coding RNA-TUG1 inhibits tumor growth and angiogenesis in hepatoblastoma

R Dong, GB Liu, BH Liu, G Chen, K Li, S Zheng… - Cell death & …, 2016 - nature.com
Hepatoblastoma is the most common liver tumor of early childhood, which is usually
characterized by unusual hypervascularity. Recently, long non-coding RNAs (lncRNA) have …

mi RNA in hepatocellular carcinoma

A Morishita, T Masaki - Hepatology Research, 2015 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide.
Despite improvements in HCC therapy, the prognosis for HCC patients remains poor due to …

The molecular ticks of the Drosophila circadian clock

O Tataroglu, P Emery - Current opinion in insect science, 2015 - Elsevier
Highlights•The Drosophila circadian pacemaker consists of transcriptional feedback
loops.•Cascades of protein phosphorylation/dephosphorylation determine period …

MicroRNAs in hepatocellular carcinoma: regulation, function, and clinical implications

J Sun, H Lu, X Wang, H Jin - The Scientific World Journal, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the
third cause of cancer‐related death. Poor understanding of the mechanisms underlying the …

miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage

DW Salzman, K Nakamura, S Nallur… - Nature …, 2016 - nature.com
MicroRNA (miRNA) expression is tightly regulated by several mechanisms, including
transcription and cleavage of the miRNA precursor RNAs, to generate a mature miRNA …

A microRNA-mediated positive feedback regulatory loop of the NF-κB pathway in Litopenaeus vannamei

H Zuo, J Yuan, Y Chen, S Li, Z Su, E Wei… - The Journal of …, 2016 - journals.aai.org
In the evolutionarily conserved canonical NF-κB pathway, degradation of the NF-κB inhibitor
IκB in the cytoplasmic NF-κB/IκB complex allows the liberated NF-κB to translocate into the …