Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …

Cardiovascular diseases (CVD) and cardiovascular risk factors are the leading cause of
death in the world today. According to the Global Burden of Disease Study, hypertension …

Patients who present with breast cancer bone metastasis only have limited palliative
treatment strategies and efficacious drug treatments are needed. In breast cancer patient …

Treatment for type 1 diabetes (T1D) requires stimulation of functional β cell regeneration and
survival under stress. Previously, we showed that inhibition of the RANKL/RANK [receptor …

Despite advances in protein engineering, the de novo design of small proteins or peptides
that bind to a desired target remains a difficult task. Most computational methods search for …

Simple Summary The pro-inflammatory cytokine, IL1β, plays a pivotal role in breast cancer
bone metastasis. Inhibiting IL-1 signalling with the IL1β specific antibody, Canakinumab, or …

Cancer imposes a substantial burden and its incidence is persistently increasing in recent
years. Cancer treatment has been difficult due to its inherently complex nature. The tumor …

Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) is a novel pro-
inflammatory factor in severe human diseases. Since inflammatory plays important roles in …

TRAF6 has emerged as a key regulator of breast cancer (BCa). However, the TRAF family
constitutes of seven members that exhibit distinct and overlapping functions. To explore …