Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly
Alzheimer's disease (AD). Depression, anxiety, and apathy are commonly observed …

The clinical and pathophysiological correlates of locus coeruleus (LC) degeneration in
Alzheimer's disease (AD) could be clarified using a method to index LC integrity in vivo …

Background and Objectives To investigate the prevalence and trajectories of
neuropsychiatric symptoms (NPS) in relation to cognitive functioning in a cohort of β-amyloid …

Background Although some human studies have reported gut microbiome changes in
individuals with Alzheimer's disease (AD) dementia or mild cognitive impairment (MCI), gut …

Apathy is one of the most prevalent, stable and persistent neuropsychiatric symptom across
the neurocognitive disorders spectrum. Recent advances in understanding of …

Background: Neuropsychiatric symptoms (NPS) are prevalent in mild cognitive impairment
(MCI), but we do not know much about their role in progression to dementia. Objective: To …

BACKGROUND/OBJECTIVES Motoric cognitive risk (MCR) syndrome is characterized by
cognitive complaints and slow gait speed in the absence of dementia. Consistent evidence …

Background Major prevention trials for Alzheimer's disease (AD) are now focusing on
multidomain lifestyle interventions. However, the exact combination of behavioral factors …

Multitarget directed ligands (MTDLs) are arising as promising tools to tackle complex
diseases. The main goal of this work is to create powerful modulating agents for …