Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is
best known for mediating axon repulsion in the developing nervous system. However, in …

The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

Netrin-1 is an evolutionarily conserved, secreted extracellular matrix protein involved in
axon guidance at the central nervous system midline,. Netrin-1 is expressed by cells …

The rhombic lip (RL) is an embryonic proliferative neuroepithelium that generates several
groups of hindbrain neurons. However, the precise boundaries and derivatives of the RL …

Clearing techniques have been developed to transparentize mouse brains, thereby
preserving 3D structure, but their complexity has limited their use. Here, we show that …

Greenfield's Neuropathology, the world's leading neuropathology reference, provides a
comprehensive account of the pathological findings in neurological disease, their biological …

The phylogenetically conserved nuclear factor I (NFI) gene family encodes site-specific
transcription factors essential for the development of a number of organ systems. We …

In most tissues, the precise control of cell migration and cell-cell interaction is of paramount
importance to the development of a functional structure. Several families of secreted …

The precise wiring of the adult mammalian CNS originates during a period of stunning
growth, guidance and plasticity that occurs during and shortly after development. When …

This article reviews symptoms and signs of aberrant axon connectivity in humans, and
summarizes major human genetic disorders that result, or have been proposed to result …