Research in the last decade has expressed considerable optimism about the clinical
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …

Psychedelic therapy has witnessed a resurgence in interest in the last decade from the
scientific and medical communities with evidence now building for its safety and efficacy in …

Ketamine is shown to enhance excitatory synaptic drive in multiple brain areas, which is
presumed to underlie its rapid antidepressant effects. Moreover, ketamine's therapeutic …

Psilocybin, a naturally occurring, tryptamine alkaloid prodrug, is currently being investigated
for the treatment of a range of psychiatric disorders. Preclinical reports suggest that the …

Pharmacological treatment of major depressive disorder (MDD) still relies on the use of
serotonergic drugs, despite their limited efficacy. A few mechanistically new drugs have …

Comment www. thelancet. com Vol 401 March 4, 2023 715 reflected in future labelling.
Trials should confirm that clinical improvements are not due to psychotherapy alone and …

Background: Emerging literature suggests that classic psychedelics may have efficacy in
treating mood and substance use disorders in humans. This has raised questions regarding …

Depression's link to serotonin dysregulation is well-known. The monoamine theory posits
that depression results from impaired serotonin activity, leading to the development of …

Research in the last decade has expressed considerable optimism about the clinical
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in a …

Alcohol use disorder (AUD) is a public health issue that affects millions of people worldwide
leading to physical, mental and socio-economic consequences. While current treatments for …