Routes for drug delivery to the eye and retina: intravitreal injections
The advantage of intravitreal injections is an immediate and increased therapeutic effect in
the intended retinal tissue. The accuracy, precision and reproducibility of the delivered …
the intended retinal tissue. The accuracy, precision and reproducibility of the delivered …
[HTML][HTML] Prefilled syringes for intravitreal drug delivery
TM Sassalos, YM Paulus - Clinical Ophthalmology (Auckland, NZ), 2019 - ncbi.nlm.nih.gov
Intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications play an
increasingly critical role in numerous retinal vascular diseases. Initially, anti-VEGF …
increasingly critical role in numerous retinal vascular diseases. Initially, anti-VEGF …
Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans
Purpose: To compare the concentration of unbound bevacizumab in the anterior chamber of
patients with macular edema, who received a single intravitreal injection of two different …
patients with macular edema, who received a single intravitreal injection of two different …
Clinical predictors of sustained intraocular pressure elevation due to intravitreal anti–vascular endothelial growth factor therapy
QV Hoang, AJ Tsuang, R Gelman, LS Mendonca… - Retina, 2013 - journals.lww.com
Purpose: We assess for frequency and predictive factors related to sustained intraocular
pressure (IOP) elevation in eyes with neovascular age-related macular degeneration …
pressure (IOP) elevation in eyes with neovascular age-related macular degeneration …
Incidence of rhegmatogenous retinal detachments after intravitreal antivascular endothelial factor injections
CH Meyer, S Michels, EB Rodrigues… - Acta …, 2011 - Wiley Online Library
Acta Ophthalmol. 2011: 89: 70–75 Abstract. Purpose: To determine the incidence of
rhegmatogenous retinal detachments (RD) after intravitreal injection in six high‐volume …
rhegmatogenous retinal detachments (RD) after intravitreal injection in six high‐volume …
[HTML][HTML] A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes
HE Lode, TT Gjølberg, S Foss, MS Sivertsen… - Scientific reports, 2019 - nature.com
Intravitreal injections of antibody-based biologics targeting vascular endothelial growth
factor (VEGF) are highly effective and have markedly decreased the risk of visual impairment …
factor (VEGF) are highly effective and have markedly decreased the risk of visual impairment …
[HTML][HTML] Accuracy and residual volume of intravitreal injection syringes in administration of very small volumes
Materials and methods We investigated three syringe models (Fig. 1): BD Plastipak 1 mL
luer slip (Becton Dickinson SA, Madrid, Spain), Omnifix-F 1 mL (B. Braun Medical Inc …
luer slip (Becton Dickinson SA, Madrid, Spain), Omnifix-F 1 mL (B. Braun Medical Inc …
Accuracy of intravenous and enteral preparations involving small volumes for paediatric use: a review
LP Ainscough, JL Ford, CW Morecroft… - European Journal of …, 2018 - ejhp.bmj.com
Background Children often need to be administered very small volumes of medicines that
are authorised for use in adults. Neonatal drug delivery is particularly challenging, and …
are authorised for use in adults. Neonatal drug delivery is particularly challenging, and …
[HTML][HTML] Anterior chamber paracentesis during intravitreal injections in observational trials: effectiveness and safety and effects
A paracentesis prior to an intravitreal injection is a very safe procedure and can prevent IOP-
spikes after injections. As these spikes pose the risk of inducing glaucomatous changes …
spikes after injections. As these spikes pose the risk of inducing glaucomatous changes …
ACCURACY AND PRECISION OF INTRAVITREAL INJECTIONS OF ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS IN REAL LIFE: What Is Actually …
I Loewenstein, M Goldstein, J Moisseiev, E Moisseiev - Retina, 2019 - journals.lww.com
Purpose: To evaluate the accuracy and precision of anti–vascular endothelial growth factor
volume delivery by intravitreal injections in the clinical setup. Methods: Volume output was …
volume delivery by intravitreal injections in the clinical setup. Methods: Volume output was …