Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …

Cytokines and chemokines are secreted proteins involved in numerous aspects of cell
growth, differentiation, and activation. A prominent feature of these molecules is their effect …

In this study we provide evidence that the SDF-1α/CXCR4 chemokine axis is involved in
both the retention of neutrophils within the bone marrow and the homing of senescent …

CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …

Chemokines regulate inflammation, leukocyte trafficking, and immune cell differentiation.
The role of chemokines in homing of naive T lymphocytes to secondary lymphatic organs is …

This study was undertaken to demonstrate the unique specificity of the chemokine receptor
CXCR4 antagonist AMD3100. Calcium flux assays with selected chemokine/cell …

T cells must migrate in order to encounter antigen-presenting cells (APCs) and to execute
their varied functions in immune defense and inflammation. ATP release and autocrine …

The important family of G protein-coupled receptors has so far not been targeted very
successfully with conventional monoclonal antibodies. Here we report the isolation and …

The chemokine-CXCL12 and its receptor, CXCR4, have recently been shown to play an
important role in regulating the directional migration of breast cancer cells to sites of …

The prevalence of asthma has risen drastically in the last two decades, with a worldwide
impact on health care systems. Although several factors contribute to the development of …