Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

RNA splicing is an essential process that governs many aspects of cellular proliferation,
survival, and differentiation. Considering the importance of RNA splicing in gene regulation …

The transferability and clinical value of genetic risk scores (GRSs) across populations
remain limited due to an imbalance in genetic studies across ancestrally diverse …

Alternative splicing (AS) is a fundamental step in eukaryotic mRNA biogenesis. Here, we
develop an efficient and reproducible pipeline for the discovery of genetic variants that affect …

Over the past decade there has been increased awareness of the potential role of
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …

Alternative splicing (AS) represents a crucial method in mRNA level to regulate gene
expression and contributes to the protein complexity. Abnormal splicing has been reported …

The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …

RNA alternative splicing, a post-transcriptional stage in eukaryotes, is crucial in cellular
homeostasis and disease processes. Due to the rapid development of the next-generation …

Although genome-wide association studies (GWAS) have identified more than 100
colorectal cancer risk loci, most of the biological mechanisms associated with these loci …

Genome-wide association studies have identified numerous variants associated with human
complex traits, most of which reside in the non-coding regions, but biological mechanisms …