Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause
liver injury and even liver failure. INH metabolism has been thought to be associated with …

Background Function and expression Arylamine N-acetyltransferases (NATs) are
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been …

Background Drug-induced liver injury (DILI) is a common complication of tuberculosis
treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of …

There is considerable evidence that susceptibility to idiosyncratic drug-induced liver injury
(DILI) is genetically determined. Though genetic associations with DILI have been reported …

Aims The aim of this study is to evaluate the potential association between N‐
acetyltransferase type 2 (NAT2) polymorphisms and drug‐induced liver injury during anti‐TB …

Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …

Isoniazid (INH) is a synthetic anti-mycobacterial agent used to treat active or latent
tuberculosis (TB). INH has been in clinical use for nearly 70 years and remains broadly …

Tuberculosis (TB) remains a major global health burden. Antitubercular drugs (ATDs) such
as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first …

Background Isoniazid [isonicotinic acid (INA) hydrazide, INH; PubChem ID 3767] 1 is a first-
line antimycobacterial agent used to treat active or latent tuberculosis (TB) infections …

Основная цель назначения лекарственного средства–избавление пациента от того
или иного заболевания, т. е. восстановление его здоровья. Фармакологический …