[HTML][HTML] Isoniazid metabolism and hepatotoxicity
Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause
liver injury and even liver failure. INH metabolism has been thought to be associated with …
liver injury and even liver failure. INH metabolism has been thought to be associated with …
PharmGKB summary: very important pharmacogene information for: N:-acetyltransferase 2
EM McDonagh, S Boukouvala, E Aklillu… - Pharmacogenetics …, 2014 - journals.lww.com
Background Function and expression Arylamine N-acetyltransferases (NATs) are
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been …
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been …
[HTML][HTML] Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study
CD Tweed, GH Wills, AM Crook, R Dawson, AH Diacon… - BMC medicine, 2018 - Springer
Background Drug-induced liver injury (DILI) is a common complication of tuberculosis
treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of …
treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of …
Genetic basis of drug-induced liver injury: present and future
There is considerable evidence that susceptibility to idiosyncratic drug-induced liver injury
(DILI) is genetically determined. Though genetic associations with DILI have been reported …
(DILI) is genetically determined. Though genetic associations with DILI have been reported …
The association between the NAT2 genetic polymorphisms and risk of DILI during anti‐TB treatment: a systematic review and meta‐analysis
M Zhang, S Wang, B Wilffert, R Tong… - British journal of …, 2018 - Wiley Online Library
Aims The aim of this study is to evaluate the potential association between N‐
acetyltransferase type 2 (NAT2) polymorphisms and drug‐induced liver injury during anti‐TB …
acetyltransferase type 2 (NAT2) polymorphisms and drug‐induced liver injury during anti‐TB …
[HTML][HTML] Human cytochrome P450 1, 2, 3 families as pharmacogenes with emphases on their antimalarial and antituberculosis drugs and prevalent African alleles
CR Chamboko, W Veldman, RB Tata… - International Journal of …, 2023 - mdpi.com
Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …
[HTML][HTML] Clinical perspectives of isoniazid-induced liver injury
S Lei, R Gu, X Ma - Liver Research, 2021 - Elsevier
Isoniazid (INH) is a synthetic anti-mycobacterial agent used to treat active or latent
tuberculosis (TB). INH has been in clinical use for nearly 70 years and remains broadly …
tuberculosis (TB). INH has been in clinical use for nearly 70 years and remains broadly …
Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms
D Ezhilarasan - Drug metabolism reviews, 2023 - Taylor & Francis
Tuberculosis (TB) remains a major global health burden. Antitubercular drugs (ATDs) such
as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first …
as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first …
PharmGKB summary: isoniazid pathway, pharmacokinetics
DJ Klein, S Boukouvala, EM McDonagh… - Pharmacogenetics …, 2016 - journals.lww.com
Background Isoniazid [isonicotinic acid (INA) hydrazide, INH; PubChem ID 3767] 1 is a first-
line antimycobacterial agent used to treat active or latent tuberculosis (TB) infections …
line antimycobacterial agent used to treat active or latent tuberculosis (TB) infections …
[PDF][PDF] Побочные действия противотуберкулезных препаратов и методы их устранения
ГС Баласанянц, ДС Суханов, ДЛ Айзиков - Тактик-Студио, СПб, 2011 - as-ma.com.ua
Основная цель назначения лекарственного средства–избавление пациента от того
или иного заболевания, т. е. восстановление его здоровья. Фармакологический …
или иного заболевания, т. е. восстановление его здоровья. Фармакологический …