[HTML][HTML] The impact of immunopeptidomics: From basic research to clinical implementation
IE Shapiro, M Bassani-Sternberg - Seminars in Immunology, 2023 - Elsevier
The immunopeptidome is the set of peptides presented by the major histocompatibility
complex (MHC) molecules, in humans also known as the human leukocyte antigen (HLA) …
complex (MHC) molecules, in humans also known as the human leukocyte antigen (HLA) …
Antigen‐specific and cross‐reactive T cells in protection and disease
Human T cells have a diverse T‐cell receptor (TCR) repertoire that endows them with the
ability to identify and defend against a broad spectrum of antigens. The universe of possible …
ability to identify and defend against a broad spectrum of antigens. The universe of possible …
[HTML][HTML] Human CD8+ T cell cross-reactivity across influenza A, B and C viruses
Abstract Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …
A subset of HLA-I peptides are not genomically templated: Evidence for cis-and trans-spliced peptide ligands
The diversity of peptides displayed by class I human leukocyte antigen (HLA) plays an
essential role in T cell immunity. The peptide repertoire is extended by various …
essential role in T cell immunity. The peptide repertoire is extended by various …
[HTML][HTML] The human immunopeptidome project: a roadmap to predict and treat immune diseases
JA Vizcaíno, P Kubiniok, KA Kovalchik, Q Ma… - Molecular & Cellular …, 2020 - ASBMB
The science that investigates the ensembles of all peptides associated to human leukocyte
antigen (HLA) molecules is termed" immunopeptidomics" and is typically driven by mass …
antigen (HLA) molecules is termed" immunopeptidomics" and is typically driven by mass …
[HTML][HTML] Predicting cross-reactivity and antigen specificity of T cell receptors
Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
[HTML][HTML] Benchmarking evolutionary tinkering underlying human–viral molecular mimicry shows multiple host pulmonary–arterial peptides mimicked by SARS-CoV-2
The hand of molecular mimicry in shaping SARS-CoV-2 evolution and immune evasion
remains to be deciphered. Here, we report 33 distinct 8-mer/9-mer peptides that are identical …
remains to be deciphered. Here, we report 33 distinct 8-mer/9-mer peptides that are identical …
[HTML][HTML] Mass spectrometry based immunopeptidomics leads to robust predictions of phosphorylated HLA class I ligands
M Solleder, P Guillaume, J Racle, J Michaux… - Molecular & Cellular …, 2020 - ASBMB
The presentation of peptides on class I human leukocyte antigen (HLA-I) molecules plays a
central role in immune recognition of infected or malignant cells. In cancer, non-self HLA-I …
central role in immune recognition of infected or malignant cells. In cancer, non-self HLA-I …
The evolving landscape of autoantigen discovery and characterization in type 1 diabetes
AW Purcell, S Sechi, TP DiLorenzo - Diabetes, 2019 - Am Diabetes Assoc
Type 1 diabetes (T1D) is an autoimmune disease that is caused, in part, by T cell–mediated
destruction of insulin-producing β-cells. High risk for disease, in those with genetic …
destruction of insulin-producing β-cells. High risk for disease, in those with genetic …
[HTML][HTML] Identification of promiscuous African swine fever virus T-cell determinants using a multiple technical approach
L Bosch-Camós, E López, MJ Navas, S Pina-Pedrero… - Vaccines, 2021 - mdpi.com
The development of subunit vaccines against African swine fever (ASF) is mainly hindered
by the lack of knowledge regarding the specific ASF virus (ASFV) antigens involved in …
by the lack of knowledge regarding the specific ASF virus (ASFV) antigens involved in …