Losing the dogmatic view of cerebral autoregulation

P Brassard, L Labrecque, JD Smirl… - Physiological …, 2021 - Wiley Online Library
Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic
review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept …

Autonomic control of cerebral blood flow: fundamental comparisons between peripheral and cerebrovascular circulations in humans

JL Koep, CE Taylor, JS Coombes… - The Journal of …, 2022 - Wiley Online Library
Understanding the contribution of the autonomic nervous system to cerebral blood flow
(CBF) control is challenging, and interpretations are unclear. The identification of calcium …

Quantification of dynamic cerebral autoregulation: welcome to the jungle!

P Brassard, MA Roy, JS Burma, L Labrecque… - Clinical Autonomic …, 2023 - Springer
Purpose Patients with dysautonomia often experience symptoms such as dizziness,
syncope, blurred vision and brain fog. Dynamic cerebral autoregulation, or the ability of the …

On the use and misuse of cerebral hemodynamics terminology using transcranial Doppler ultrasound: a call for standardization

RJ Skow, RM Brothers… - American Journal …, 2022 - journals.physiology.org
Cerebral hemodynamics, eg, cerebral blood flow, can be measured and quantified using
many different methods, with transcranial Doppler ultrasound (TCD) being one of the most …

The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex

RB Panerai, A Davies, RH Clough… - Journal of Cerebral …, 2024 - journals.sagepub.com
The cerebral circulation responds differently to increases in mean arterial pressure (MAP),
compared to reductions in MAP. We tested the hypothesis that this directional sensitivity is …

Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke

AA Whitaker, S Waghmare… - Journal of Cerebral …, 2024 - journals.sagepub.com
High-intensity interval training (HIIE) may present unique challenges to the cerebrovascular
system in individuals post-stroke. We hypothesized lower middle cerebral artery blood …

The influence of physiological and pathological perturbations on blood-brain barrier function

N Zhao, TD Chung, Z Guo, JJ Jamieson… - Frontiers in …, 2023 - frontiersin.org
The blood-brain barrier (BBB) is located at the interface between the vascular system and
the brain parenchyma, and is responsible for communication with systemic circulation and …

Reproducibility and diurnal variation of the directional sensitivity of the cerebral pressure-flow relationship in men and women

L Labrecque, JS Burma, MA Roy… - Journal of Applied …, 2022 - journals.physiology.org
The cerebral pressure-flow relationship has directional sensitivity, meaning the
augmentation in cerebral blood flow is attenuated when mean arterial pressure (MAP) …

Directional sensitivity of dynamic cerebral autoregulation during spontaneous fluctuations in arterial blood pressure at rest

RB Panerai, SC Barnes, AP Batterham… - Journal of Cerebral …, 2023 - journals.sagepub.com
Directional sensitivity, the more efficient response of cerebral autoregulation to increases,
compared to decreases, in mean arterial pressure (MAP), has been demonstrated with …

Directional sensitivity of the cerebral pressure–flow relationship in young healthy individuals trained in endurance and resistance exercise

MA Roy, L Labrecque, BG Perry, S Korad… - Experimental …, 2022 - Wiley Online Library
New Findings What is the central question of this study? Does habitual exercise modality
affect the directionality of the cerebral pressure–flow relationship? What is the main finding …